Steinkampf Michael P, Dharia Sejal P, Dickerson Ryan D
Department of Obsterics and Gynacology, Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, Birmingham, Alabama 35249-7333, USA.
Fertil Steril. 2003 Sep;80(3):643-5. doi: 10.1016/s0015-0282(03)00758-1.
To report the first case of monozygotic twins with discordant congenital anomalies.
Descriptive case report.
University hospital.
PATIENT(S): A 20-year woman with complete vaginal agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome) and right renal agenesis presented for creation of a neovagina. She had a monozygous twin confirmed by DNA testing using short tandem repeat (STR) loci; the twin had normal mullerian/mesonephric development but isolated bilateral tibial longitudinal deficiency.
INTERVENTION(S): The complete history, physical, and laboratory data of both the patient and her twin. Also, operative laparoscopy with creation of a neovagina in the patient.
MAIN OUTCOME MEASURE(S): Diagnosis and appropriate treatment of Mayer-Rokitansky-Kuster-Hauser syndrome and DNA testing with STR loci for monozygosity.
RESULT(S): The surgical resection of the bilateral uterine remnants, creation of a neovagina in the patient, and the demonstration of monozygosity with her twin with bilateral tibial longitudinal deficiency.
CONCLUSION(S): This case report suggests a link between developmental abnormalities of the genital and skeletal system.
