Uozumi J, Koikawa Y, Ueda T
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Pharmacobiodyn. 1992 Dec;15(12):693-7. doi: 10.1248/bpb1978.15.693.
Male Sprague-Dawley rats were given either 6.5 or 8.5 mg/kg of iv cisplatin combined with three injections of sc methylprednisolone in doses of either 50, 100 or 250 mg/kg at -4, 0 and 4 h after the cisplatin injection. Blood urea nitrogen and serum creatinine levels were determined on day 5 following the cisplatin injection. The protective effects of methylprednisolone on cisplatin-induced nephrotoxicity were clearly demonstrated. Our preliminary results suggest that a much higher dose of cisplatin could be injected in cancer chemotherapy, if it was combined with methylprednisolone.
给雄性Sprague-Dawley大鼠静脉注射6.5或8.5毫克/千克顺铂，并在顺铂注射后-4、0和4小时皮下注射三次甲基强的松龙，剂量分别为50、100或250毫克/千克。在顺铂注射后第5天测定血尿素氮和血清肌酐水平。甲基强的松龙对顺铂诱导的肾毒性的保护作用得到了明确证实。我们的初步结果表明，如果将顺铂与甲基强的松龙联合使用，在癌症化疗中可以注射更高剂量的顺铂。
