Koikawa Y, Uozumi J, Yasumasu T, Ueda T, Kumazawa J
Dept. of Urology, Faculty of Medicine, Kyushu University, School of Medicine.
Gan To Kagaku Ryoho. 1993 Aug;20(10):1363-7.
Cis-diamminedichloroplatinum (II) (cisplatin) is a very effective antitumor drug, but It has an adverse effect of nephrotoxicity. There are many reports concerning protective agents against cisplatin nephrotoxicity, but clinically useful modalities are very few. In the present study, prophylactic effects of methylprednisolone (MP) on cisplatin-induced nephrotoxicity were examined. Male Sprague-Dawley rats were injected iv with 6.5 mg/kg of cisplatin combined with a subcutaneous MP given sc in various doses at various timing. Rats were killed 5 days after cisplatin injection to determine BUN and serum creatinine levels. BUN and serum creatinine levels in rats pretreated with MP 4 or 2 hr before cisplatin injection were significantly lower than those in rats received cisplatin alone. Our preliminary results suggest that pretreatment with MP is an effective means of protection against cisplatin-induced nephrotoxicity.
顺二氯二氨铂（II）（顺铂）是一种非常有效的抗肿瘤药物，但它有肾毒性的副作用。关于顺铂肾毒性保护剂的报道很多，但临床上有用的方法却很少。在本研究中，检测了甲泼尼龙（MP）对顺铂诱导的肾毒性的预防作用。雄性Sprague-Dawley大鼠静脉注射6.5mg/kg顺铂，并在不同时间皮下注射不同剂量的MP。顺铂注射5天后处死大鼠，测定尿素氮（BUN）和血清肌酐水平。在顺铂注射前4或2小时用MP预处理的大鼠的BUN和血清肌酐水平显著低于单独接受顺铂的大鼠。我们的初步结果表明，MP预处理是预防顺铂诱导的肾毒性的有效手段。
