Ashenden Michael J, Gore Christopher J, Parisotto Robin, Sharpe Ken, Hopkins Will G, Hahn Allan G
Science and Industry against Blood doping, Gold Coast QLD 4217, Australia.
Haematologica. 2003 Sep;88(9):1053-62.
ON- and OFF-model scores derived from blood parameters sensitive to erythropoiesis have been shown to be a useful tool to identify athletes who are currently injecting erythropoietin to enhance performance or those who have recently stopped doing so. We investigated changes in blood parameters and model scores during and after exposure to terrestrial and simulated altitudes.
We retrospectively evaluated changes in hematologic data collected from 19 elite cyclists who lived and trained 2690 m above sea level for 26-31 days, from six elite Kenyan runners who lived 2100 m above sea level but descended to compete at sea level competitions, and from 39 well-trained subjects who resided at sea level but slept at a simulated altitude of 2650-3000 m for 20-23 days of either consecutive or intermittent nightly exposure.
Upon ascent to a terrestrial altitude, ON- and OFF-model scores increased immediately, mainly because of an increase in hemoglobin concentration. Scores had not returned fully to baseline three weeks after return to sea level, because of the persistence of the raised hemoglobin concentration for the ON and OFF scores and a fall in reticulocyte percentage for OFF scores. Effects were smaller or negligible for simulated altitude. For Kenyan runners, ON- and OFF-model scores decreased within seven days of descent to sea level.
Our results reinforce the notion that caution should be exercised when interpreting blood results from athletes who have recently been exposed to either terrestrial or simulated altitude, and appropriate allowance should be made for the effect of altitude on blood model scores.
源自对红细胞生成敏感的血液参数的“模型开启”和“模型关闭”评分已被证明是一种有用的工具，可用于识别当前正在注射促红细胞生成素以提高成绩的运动员或最近停止注射的运动员。我们研究了暴露于陆地海拔和模拟海拔期间及之后血液参数和模型评分的变化。
我们回顾性评估了从19名精英自行车运动员收集的血液学数据变化，这些运动员在海拔2690米处生活和训练26至31天；6名精英肯尼亚跑步运动员，他们生活在海拔2100米处，但下降到海平面参加比赛；以及39名训练有素的受试者，他们居住在海平面，但连续或间歇性夜间暴露于2650 - 3000米的模拟海拔处20至23天。
上升到陆地海拔后，“模型开启”和“模型关闭”评分立即增加主要是由于血红蛋白浓度增加。回到海平面三周后，评分尚未完全恢复到基线，因为“模型开启”和“模型关闭”评分中血红蛋白浓度持续升高，且“模型关闭”评分中网织红细胞百分比下降。模拟海拔的影响较小或可忽略不计。对于肯尼亚跑步运动员，下降到海平面七天内“模型开启”和“模型关闭”评分降低。
我们的结果强化了这样一种观念，即对近期暴露于陆地或模拟海拔的运动员的血液检测结果进行解读时应谨慎，并应适当考虑海拔对血液模型评分的影响。
