Tracy Russell P
Laboratory for Clinical Biochemistry Research, College of Medicine, University of Vermont, Colchester, VT 05446, USA.
Chest. 2003 Sep;124(3 Suppl):49S-57S. doi: 10.1378/chest.124.3_suppl.49s.
The exploration of coagulation led to identifying inflammation as a major factor in arterial disease throughout life. "Integrative molecular physiology" reflects our emerging understanding of how coagulation and inflammation integrate with one another, in both normal physiology and in pathophysiology. Our own responses to environmental challenge provide much of the damage that cumulatively results in chronic cardiovascular disease. Only by intervening in exquisitely precise ways can we hope to effectively and safely modify the course of lifelong chronic diseases, such as atherosclerosis.
对凝血的探索使人们认识到炎症是贯穿一生的动脉疾病的主要因素。“整合分子生理学”反映了我们对凝血与炎症在正常生理学和病理生理学中如何相互整合的新认识。我们自身对环境挑战的反应造成了许多损害，这些损害累积起来导致了慢性心血管疾病。只有通过极其精确的干预方式，我们才有希望有效且安全地改变诸如动脉粥样硬化等终身慢性疾病的病程。
