树突状细胞：其在肠道炎症中的作用及其与肠道细菌的关系。
The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.
作者信息
Stagg A J, Hart A L, Knight S C, Kamm M A
机构信息
Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, UK.
出版信息
Gut. 2003 Oct;52(10):1522-9. doi: 10.1136/gut.52.10.1522.
Abstract
Dendritic cells are antigen presenting cells that are likely to be pivotal in the balance between tolerance and active immunity to commensal microorganisms that is fundamental to inflammatory conditions, including Crohn's disease and ulcerative colitis. Interactions between dendritic cells and microbial products are discussed and how they contribute to regulation of immune responses. The concept that interactions between dendritic cells and commensal organisms may be responsible for maintaining intestinal immune homeostasis is also explored.
摘要
树突状细胞是抗原呈递细胞，在对共生微生物的耐受与主动免疫之间的平衡中可能起关键作用，而这种平衡对于包括克罗恩病和溃疡性结肠炎在内的炎症性疾病至关重要。本文讨论了树突状细胞与微生物产物之间的相互作用，以及它们如何促进免疫反应的调节。还探讨了树突状细胞与共生生物之间的相互作用可能负责维持肠道免疫稳态这一概念。
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本文引用的文献
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Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis.CD4 + T细胞诱导的结肠炎小鼠的结肠固有层树突状细胞
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Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease.克罗恩病患者结肠黏膜中DC-SIGN+IL-12+IL-18+和CD83+IL-12-IL-18-树突状细胞群体的表达增加。
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DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.DC-SIGN是人类树突状细胞上主要的结核分枝杆菌受体。
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Mycobacteria target DC-SIGN to suppress dendritic cell function.分枝杆菌靶向DC-SIGN以抑制树突状细胞功能。
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