Stagg A J, Hart A L, Knight S C, Kamm M A
Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, UK.
Gut. 2003 Oct;52(10):1522-9. doi: 10.1136/gut.52.10.1522.
Dendritic cells are antigen presenting cells that are likely to be pivotal in the balance between tolerance and active immunity to commensal microorganisms that is fundamental to inflammatory conditions, including Crohn's disease and ulcerative colitis. Interactions between dendritic cells and microbial products are discussed and how they contribute to regulation of immune responses. The concept that interactions between dendritic cells and commensal organisms may be responsible for maintaining intestinal immune homeostasis is also explored.
树突状细胞是抗原呈递细胞,在对共生微生物的耐受与主动免疫之间的平衡中可能起关键作用,而这种平衡对于包括克罗恩病和溃疡性结肠炎在内的炎症性疾病至关重要。本文讨论了树突状细胞与微生物产物之间的相互作用,以及它们如何促进免疫反应的调节。还探讨了树突状细胞与共生生物之间的相互作用可能负责维持肠道免疫稳态这一概念。