Gürbüz M Kezban, Ozüdoğru Erkan N, Cakli Hamdi, Cingi Emre, Keçik M Cem, Cingi Cemal
Department of Otolaryngology, Medicine Faculty of Osmangazi University, Eskişehir, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2003 May;10(5):194-8.
We evaluated the surgical techniques employed and survival rates in patients who were treated for early glottic cancer.
The study included 29 patients (28 males, 1 female; mean age 59 years; range 47 to 73 years) who underwent surgery for early glottic cancer. Surgical techniques were employed in view of factors such as involvement of the anterior commissure, the extent of sub- or supraglottic invasion, and cord mobility. Two- and five-year survival rates were calculated. TNM classification was made according to the 1992 AJCC staging system.
Preoperative tumor stages were TisN0 (n=2, 7%), T1N0 (n=20, 69%), and T2N0 (n=7, 24%). Surgical techniques included laryngofissure and cordectomy (n=9, 31%), frontolateral laryngectomy (n=18, 62%), and vertical hemilaryngectomy (n=2, 7%). Positive surgical margins were reported postoperatively in 10 patients, eight of whom remained tumor-free with (n=4) or without (n=4) radiation therapy during the follow-up period, while two patients underwent total laryngectomy because of local recurrences. Three patients died due to causes other than the primary disease. Two- and five-year survival rates were 88.8% and 80%, respectively.
Involvement of the anterior commissure, and the extent of invasion to the subglottis, supraglottis, and the laryngeal ventricle seem to play a major role in selecting the most appropriate surgical technique in early glottic cancer.
我们评估了早期声门癌患者所采用的手术技术及生存率。
本研究纳入了29例接受早期声门癌手术的患者(28例男性,1例女性;平均年龄59岁;范围47至73岁)。根据前联合受累、声门下或声门上侵犯范围以及声带活动度等因素采用手术技术。计算了2年和5年生存率。根据1992年美国癌症联合委员会(AJCC)分期系统进行TNM分类。
术前肿瘤分期为TisN0(n = 2,7%)、T1N0(n = 20,69%)和T2N0(n = 7,24%)。手术技术包括喉裂开声带切除术(n = 9,31%)、额侧喉切除术(n = 18,62%)和垂直半喉切除术(n = 2,7%)。术后报告10例手术切缘阳性,其中8例在随访期间接受(n = 4)或未接受(n = 4)放疗后无瘤生存,而2例患者因局部复发接受了全喉切除术。3例患者因原发性疾病以外的原因死亡。2年和5年生存率分别为88.8%和80%。
前联合受累以及声门下、声门上和喉室的侵犯范围似乎在早期声门癌选择最合适的手术技术中起主要作用。