Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS.

Suppr

超能文献

作者信息

Chim C S, Fung T K, Liang R

出版信息

Leukemia. 2003 Dec;17(12):2533-5. doi: 10.1038/sj.leu.2403133.

DOI:10.1038/sj.leu.2403133

PMID:12970764

Abstract

摘要

相似文献

Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS.

Leukemia. 2003 Dec;17(12):2533-5. doi: 10.1038/sj.leu.2403133.

Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma.

Leukemia. 2002 Sep;16(9):1844-51. doi: 10.1038/sj.leu.2402609.

Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias.

Ann Hematol. 2003 Dec;82(12):738-42. doi: 10.1007/s00277-003-0744-8. Epub 2003 Sep 25.

Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.

Cancer Res. 1998 Jun 15;58(12):2624-32.

Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes.

Exp Cell Res. 1999 Dec 15;253(2):561-72. doi: 10.1006/excr.1999.4688.

The role of p16-cyclin d/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma.

Br J Cancer. 2000 Feb;82(3):675-82. doi: 10.1054/bjoc.1999.0980.

Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma.

Cancer Res. 2005 Dec 15;65(24):11345-53. doi: 10.1158/0008-5472.CAN-05-2159.

Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma.

Hum Pathol. 2007 Dec;38(12):1849-57. doi: 10.1016/j.humpath.2007.05.009. Epub 2007 Sep 27.

Role of cdk4, p16INK4, and Rb expression in the prognosis of bronchioloalveolar carcinomas.

Respiration. 2005 Jan-Feb;72(1):68-73. doi: 10.1159/000083403.

Analysis of methylation pattern in multiple myeloma.

Acta Haematol. 2005;114 Suppl 1:23-6. doi: 10.1159/000087041.

引用本文的文献

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications.

MedComm (2020). 2025 Aug 3;6(8):e70322. doi: 10.1002/mco2.70322. eCollection 2025 Aug.

Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?

Front Oncol. 2022 Aug 18;12:979569. doi: 10.3389/fonc.2022.979569. eCollection 2022.

Clinicopathological significance of the hypermethylation in multiple myeloma, a systematic review and meta-analysis.

Oncotarget. 2017 Jun 27;8(47):83270-83279. doi: 10.18632/oncotarget.18742. eCollection 2017 Oct 10.

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment.

BMC Cancer. 2015 May 30;15:444. doi: 10.1186/s12885-015-1460-1.

Methylation of miR124a-1, miR124a-2, and miR124a-3 in Hodgkin lymphoma.

Tumour Biol. 2015 Mar;36(3):1963-71. doi: 10.1007/s13277-014-2802-3. Epub 2014 Nov 15.

Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.

Oncol Lett. 2014 Nov;8(5):2130-2134. doi: 10.3892/ol.2014.2481. Epub 2014 Aug 26.

The role of epigenetics in the biology of multiple myeloma.

Blood Cancer J. 2014 May 2;4(5):e207. doi: 10.1038/bcj.2014.29.

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma.

Leukemia. 2015 Jan;29(1):196-206. doi: 10.1038/leu.2014.135. Epub 2014 Apr 15.

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.

Oncotarget. 2013 Dec;4(12):2186-207. doi: 10.18632/oncotarget.1497.

Environmental chemical exposures and human epigenetics.

Int J Epidemiol. 2012 Feb;41(1):79-105. doi: 10.1093/ije/dyr154. Epub 2011 Dec 13.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验