Yu Huiqing, Yang Liejun, Fu Yunfeng, Gao Meng, Tian Ling
Department of Medical Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing 400030, China.
The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Oncotarget. 2017 Jun 27;8(47):83270-83279. doi: 10.18632/oncotarget.18742. eCollection 2017 Oct 10.
It is well known that the loss of function of the gene is mainly caused by the hypermethylation of the gene; however, whether or not the inactivation is associated with the clinical significance of multiple myeloma (MM) remains elusive. A meta-analysis was conducted to quantitatively determine the role of the hypermethylation in the clinical significance of MM. We demonstrated that MM patients show much higher hypermethylation rates on the gene in bone marrow compared to normal individuals, as well as monoclonal gammopathy of undetermined significance (MGUS). The difference of aberrant hypermethylation between MM patients in advanced stage and MM patients in early stage is not statistically significant. Interestingly, the survival rate of MM patients with the hypermethylation is much shorter compared to those without the hypermethylation. Our results demonstrate that hypermethylation status of the gene may play a role in the progression of MGUS to MM, as well as worse survival in MM. The hypermethylation, which induces the loss of function of the gene that plays a critical role in the early tumorigenesis of MM.
众所周知，该基因功能丧失主要由该基因的高甲基化引起；然而，其失活是否与多发性骨髓瘤（MM）的临床意义相关仍不清楚。进行了一项荟萃分析以定量确定该基因高甲基化在MM临床意义中的作用。我们证明，与正常个体以及意义未明的单克隆丙种球蛋白病（MGUS）相比，MM患者骨髓中该基因的高甲基化率要高得多。晚期MM患者和早期MM患者之间异常高甲基化的差异无统计学意义。有趣的是，该基因高甲基化的MM患者的生存率比没有该基因高甲基化的患者短得多。我们的结果表明，该基因的高甲基化状态可能在MGUS向MM的进展中起作用，以及在MM中导致更差的生存率。该基因的高甲基化诱导了在MM早期肿瘤发生中起关键作用的该基因功能丧失。
