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3
Transcription factor EGR-1 inhibits growth of hepatocellular carcinoma and esophageal carcinoma cell lines.转录因子EGR-1抑制肝癌和食管癌细胞系的生长。
World J Gastroenterol. 2002 Apr;8(2):203-7. doi: 10.3748/wjg.v8.i2.203.
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Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.将视黄酸受体α和γ过表达于肿瘤性表皮细胞会导致视黄酸诱导的生长停滞和细胞凋亡。
Carcinogenesis. 2001 Dec;22(12):1955-63. doi: 10.1093/carcin/22.12.1955.
5
Immune function, telomerase, and angiogenesis in patients with primary, operable nonsmall cell lung carcinoma: tumor size and lymph node status remain the most important prognostic features.原发性可手术非小细胞肺癌患者的免疫功能、端粒酶与血管生成：肿瘤大小和淋巴结状态仍是最重要的预后特征。
Cancer. 2001 Nov 15;92(10):2648-57. doi: 10.1002/1097-0142(20011115)92:10<2648::aid-cncr1618>3.0.co;2-7.
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Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine.小鼠肠道自发凋亡和辐射诱导凋亡过程中的半胱天冬酶激活
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Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells.正常人乳腺上皮细胞的视黄酸生物合成是通过醛脱氢酶6进行的，MCF-7细胞中不存在该酶。
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8
In situ detection of telomerase enzymatic activity in human hepatocellular carcinogenesis.人肝细胞癌发生过程中端粒酶活性的原位检测
J Pathol. 2001 Aug;194(4):459-65. doi: 10.1002/path.901.
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Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid.抗早幼粒细胞白血病（PML）肽核酸对急性早幼粒细胞白血病细胞中早幼粒细胞白血病（PML）/维甲酸受体α及PML表达的抑制作用
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全反式维甲酸对人肝癌细胞增殖的抑制作用。

Inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell proliferation.

作者信息

Piao Yun-Feng, Shi Yang, Gao Pu-Jun

机构信息

Department of Gastroenterology, the First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.

出版信息

World J Gastroenterol. 2003 Sep;9(9):2117-20. doi: 10.3748/wjg.v9.i9.2117.

DOI:10.3748/wjg.v9.i9.2117
PMID:12970919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4656687/
Abstract

AIM

To study the inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell line SMMC-7721 and to explore the mechanism of its effect.

METHODS

SMMC-7721 cells were divided into two groups, one treated with all-trans retinoic acid (ATRA) for 5 days and the other as a control group. Light microscope and electron microscope were used to observe the morphological changes. Telomerase activity was analyzed with silver-stained telomere repeated assay protocal (TRAP). Expression of Caspase-3 was demonstrated with western blot.

RESULTS

ATRA-treated cells showed differentiation features including small and pyknotic nuclei, densely stained chromatin and fewer microvilli. Besides, ATRA could inhibit the activity of telomerase, promote the expression of Caspase-3 and its activation.

CONCLUSION

Telomerase activity and Caspase-3 expression are changed in human hepatocellular carcinoma cell line SMMC-7721 treated with all-trans retinioc acid. The inhibition of telomerase activity and the activation of Caspase-3 may be the key steps through which ATRA inhibits the proliferation of SMMC-7721 cell line.

摘要

目的

研究全反式维甲酸对人肝癌细胞系SMMC - 7721的抑制作用，并探讨其作用机制。

方法

将SMMC - 7721细胞分为两组，一组用全反式维甲酸（ATRA）处理5天，另一组作为对照组。用光镜和电镜观察形态学变化。采用银染端粒重复序列分析方法（TRAP）分析端粒酶活性。用蛋白质免疫印迹法检测Caspase - 3的表达。

结果

经ATRA处理的细胞呈现出分化特征，包括细胞核小而固缩、染色质致密、微绒毛减少。此外，ATRA可抑制端粒酶活性，促进Caspase - 3的表达及其激活。

结论

全反式维甲酸处理的人肝癌细胞系SMMC - 7721中端粒酶活性和Caspase - 3表达发生改变。抑制端粒酶活性和激活Caspase - 3可能是ATRA抑制SMMC - 7721细胞系增殖的关键步骤。