Yang Yun-mei, Lu Xue-ying, Huang Wei-dong, Shen Mei-ya
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Aug;32(4):339-41. doi: 10.3785/j.issn.1008-9292.2003.04.017.
To investigate the effect of thymosin alpha 1 on cellular immune function in the elderly patients with malignant tumor.
Thirty patients with malignant tumor were injected with thymosin alpha 1 subcutaneously at the dose of 1.6 mg q.d. for the first month and q.o.d. for the following month. The number of T cell subgroups and the activity of NK cell in peripheral blood were detected and the quality of life of the patients were evaluated before treatment and at the end of treatment.
Treatment of thymosin alpha 1 increased the number of CD4 cells and improved the NK activity, and also improved the quality of life of the elderly patients with malignant tumor. There were no side effects found.
Thymosin alpha 1 can enhance the cellular immune function of the elderly patients with malignant tumor.
探讨胸腺肽α1对老年恶性肿瘤患者细胞免疫功能的影响。
30例恶性肿瘤患者，第一个月皮下注射胸腺肽α1，剂量为1.6mg每日1次，随后一个月改为隔日1次。在治疗前及治疗结束时检测外周血T细胞亚群数量及NK细胞活性，并评估患者的生活质量。
胸腺肽α1治疗增加了CD4细胞数量，提高了NK活性，同时改善了老年恶性肿瘤患者的生活质量。未发现副作用。
胸腺肽α1可增强老年恶性肿瘤患者的细胞免疫功能。
