Favalli C, Jezzi T, Mastino A, Rinaldi-Garaci C, Riccardi C, Garaci E
Cancer Immunol Immunother. 1985;20(3):189-92. doi: 10.1007/BF00205574.
A single injection of alpha beta-interferon (alpha beta-IFN) (30000 units/mouse), a major biological modifier of natural killer (NK) cytolytic activity, strongly stimulated NK activity in normal mice, as expected, while the same treatment did not statistically alter the NK response in cyclophosphamide (CY)-suppressed animals. We investigated the possibility of thymosin alpha 1 cooperating with alpha beta-IFN in boosting NK activity in CY-suppressed animals. The results show that treatment with thymosin alpha 1 (200 micrograms/kg) for 4 days, followed by a single injection of alpha beta-IFN 24 h before testing, strongly restored NK activity in CY-suppressed mice. Thymosin alpha 1 was, moreover, able to accelerate the recovery rate of NK activity in bone marrow reconstituted murine chimeras. Taken together the data support the concept that the synergic effect between thymosin alpha 1 and alpha beta-IFN could be the result of effects on differentiation of the NK lineage at different levels.
单次注射αβ干扰素（αβ-IFN）（30000单位/只小鼠），这是自然杀伤（NK）细胞溶解活性的一种主要生物调节剂，正如预期的那样，它能强烈刺激正常小鼠的NK活性，而相同的处理在统计学上并未改变环磷酰胺（CY）抑制动物的NK反应。我们研究了胸腺素α1与αβ-IFN协同作用增强CY抑制动物NK活性的可能性。结果表明，用胸腺素α1（200微克/千克）处理4天，然后在测试前24小时单次注射αβ-IFN，能强烈恢复CY抑制小鼠的NK活性。此外，胸腺素α1能够加速骨髓重建的小鼠嵌合体中NK活性的恢复率。综合这些数据支持了这样一种观点，即胸腺素α1与αβ-IFN之间的协同作用可能是对NK谱系不同水平分化产生影响的结果。
