Mosnier J F, Fléjou J F, Potet F, Rotenberg A, Goldfain D
Service d'Anatomie et de Cytologie pathologiques, Hôpital Beaujon, Clichy.
Presse Med. 1992;21(44):2135-8.
Helicobacter pylori is known to be responsible for most cases of chronic gastritis, but its role in the outcome of gastric ulcer is unknown. The purpose of this study was to determine the prevalence of H. pylori infection before and after treatment of gastric ulcer, the micro-organism being untreated. The trial involved 26 patients with an acute episode of gastric ulcer, who had undergone endoscopy with biopsy of the antrum, the fundus and the ulcer rim at the initial examination and then 6 weeks and 1 year after the diagnosis. At day 0, 25 acute ulcers were associated with chronic H. pylori gastritis; one patient had neither gastritis nor H. pylori infection. The H. pylori count correlated with the activity of chronic gastritis and with the extension of intestinal metaplasia; it was not modified by the healing of gastric ulcer observed in 24/26 patients on day 360. These results confirm the existence of a close association between H. pylori, chronic gastritis and gastric ulcer. It also suggests that H. pylori is not directly involved in the healing or recurrence of gastric ulcer.
已知幽门螺杆菌是大多数慢性胃炎病例的病因，但它在胃溃疡转归中的作用尚不清楚。本研究的目的是确定胃溃疡治疗前后幽门螺杆菌感染的患病率，该微生物未接受治疗。该试验纳入了26例胃溃疡急性发作患者，这些患者在初次检查时接受了胃镜检查，并对胃窦、胃底和溃疡边缘进行了活检，然后在诊断后的6周和1年进行复查。在第0天，25例急性溃疡与慢性幽门螺杆菌胃炎相关；1例患者既无胃炎也无幽门螺杆菌感染。幽门螺杆菌计数与慢性胃炎的活动度及肠化生的范围相关；在第360天，24/26例患者的胃溃疡愈合，但幽门螺杆菌计数未改变。这些结果证实了幽门螺杆菌、慢性胃炎和胃溃疡之间存在密切关联。这也表明幽门螺杆菌与胃溃疡的愈合或复发无直接关系。
