Kang J K, Kim E, Kim K H, Oh S H
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1991 Jun;32(2):157-68. doi: 10.3349/ymj.1991.32.2.157.
The occurrence of Helicobacter pylori(H.pylori) and its relationship with gastric mucosa were studied by light and electron microscopy and culture of biopsy specimens from gastric mucosa of 160 patients with upper gastrointestinal symptoms. H. pylori were present in 96.6% of patients with active chronic gastritis, 100% of patients with duodenal ulcer and 76.9% of patients with gastric ulcer, while present in only 6.3% of individuals with histologically normal gastric mucosa. The bacteria colonized the antral mucosa more frequently than the body or than the duodenal cap mucosa. The bacteria were rarely seen in the intestinalized epithelium per se, but there was no significant difference in prevalence of H. pylori between gastritis with intestinal metaplasia and gastritis without intestinal metaplasia. H. pylori could be seen in close association with the surface of gastric epithelial cells below the mucus layer without evidence of intracellular parasitism, All of the strains tested were susceptible to penicillin, erythromycin, and most of them susceptible to tinidazole and bismuth salts. It is concluded that H. pylori are highly associated with gastritis and peptic ulcer diseases and its prevalence rates in patients with those diseases is higher than in developed countries. This strong association of H. pylori infection with gastritis and peptic ulcer diseases suggest a possible etiologic role for the bacterium in those diseases.
通过光学显微镜、电子显微镜以及对160例有上消化道症状患者胃黏膜活检标本进行培养，研究幽门螺杆菌（H.pylori）的发生情况及其与胃黏膜的关系。活动性慢性胃炎患者中96.6%存在幽门螺杆菌，十二指肠溃疡患者中100%存在，胃溃疡患者中76.9%存在，而在组织学上胃黏膜正常的个体中仅6.3%存在。该菌在胃窦黏膜的定植比胃体或十二指肠球部黏膜更常见。在肠化生上皮本身很少见到该菌，但在伴有肠化生的胃炎和不伴有肠化生的胃炎中，幽门螺杆菌的患病率无显著差异。幽门螺杆菌可见于黏液层下方与胃上皮细胞表面紧密相连处，无细胞内寄生证据。所有检测菌株对青霉素、红霉素敏感，大多数对替硝唑和铋盐敏感。结论是，幽门螺杆菌与胃炎和消化性溃疡疾病高度相关，这些疾病患者中的幽门螺杆菌患病率高于发达国家。幽门螺杆菌感染与胃炎和消化性溃疡疾病的这种强关联表明该菌在这些疾病中可能起病因学作用。
