Bush A I, Beyreuther K, Masters C L
Department of Pathology, University of Melbourne, Parkville, Australia.
Pharmacol Ther. 1992;56(1):97-117. doi: 10.1016/0163-7258(92)90039-3.
The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.
现已了解，β-淀粉样蛋白A4在阿尔茨海默病的发展过程中起关键作用。这种蛋白质是由淀粉样蛋白前体（一种大型膜糖蛋白）的异常加工产生的。深入了解这种异常加工的机制将为设计治疗阿尔茨海默病的新策略提供相关信息。
