Ishiura S
National Institute of Neuroscience, NCNP, Tokyo, Japan.
J Neurochem. 1991 Feb;56(2):363-9. doi: 10.1111/j.1471-4159.1991.tb08160.x.
Amyloid A4 protein (beta-protein) is deposited in the brain of a patient with Alzheimer's disease (AD) as one of the main components of extracellular cerebrovascular amyloid, as well as neurofibrillary tangles. It is derived from a precursor protein, and its formation has been considered to be a rate-limiting step for brain degeneration in AD. In this article, proteolytic cleavage events that can degrade amyloid precursor protein are reviewed with respect to how the topographical distribution of the proteinase and its substrates disturbs normal processing steps in AD brain.
淀粉样蛋白A4（β-蛋白）作为细胞外脑血管淀粉样蛋白以及神经原纤维缠结的主要成分之一，沉积在阿尔茨海默病（AD）患者的大脑中。它来源于一种前体蛋白，其形成被认为是AD脑退变的限速步骤。在本文中，就蛋白酶及其底物的拓扑分布如何干扰AD脑的正常加工步骤，对可降解淀粉样前体蛋白的蛋白水解切割事件进行了综述。
