口服伤寒疫苗在泰国儿童中的可接受性。

Acceptability of oral typhoid vaccine in Thai children.

作者信息

Mekmullica Jutarat, Pancharoen Chitsanu

机构信息

Department of Pediatrics, Bhumibol Adulyadej Hospital, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2003 Jun;34(2):334-6.

PMID:12971558

Abstract

To determine the acceptability of oral typhoid vaccine to Thai children, 434 volunteers, aged 4-15 years (average age = 8.2 years), were assigned to take three capsules of oral typhoid vaccine (one capsule every other day). Success was defined as the subjects' being able to swallow all three capsules. Information concerning the subjects' level of education, eating habits, and ability to take medicines in a variety of preparations (syrups, tablets and capsules) was obtained. The overall success rate was 94.2%; the rates were 84.4%, 94.9%, and 100% in the age groups 4-6 years, 7-9 years, and 10-12 years respectively. The rates were 82%, 85.7%, 93.3%, 96.4%, 98.8%, 100% and 100% in the students of kindergarten 1, kindergarten 2, elementary grade 1, grade 2, grade 3, grade 4, and grade 5 respectively. There was a correlation between a child's prior ability to take tablets/capsules and his success in swallowing the oral typhoid vaccine.

摘要

为确定口服伤寒疫苗对泰国儿童的可接受性，434名年龄在4至15岁（平均年龄 = 8.2岁）的志愿者被分配服用三粒口服伤寒疫苗胶囊（每隔一天服用一粒）。成功的定义为受试者能够吞下所有三粒胶囊。获取了有关受试者教育程度、饮食习惯以及服用各种制剂（糖浆、片剂和胶囊）药物能力的信息。总体成功率为94.2%；4至6岁、7至9岁和10至12岁年龄组的成功率分别为84.4%、94.9%和100%。幼儿园1班、幼儿园2班、小学1年级、2年级、3年级、4年级和5年级学生的成功率分别为82%、85.7%、93.3%、96.4%、98.8%、100%和100%。儿童先前服用片剂/胶囊的能力与其成功吞咽口服伤寒疫苗之间存在相关性。