口服伤寒和副伤寒乙灭活疫苗及气雾化学伤寒疫苗在对照现场试验中的有效性评估。

Assessment of effectivity of oral killed typhoid and paratyphoid B vaccines and aerosol chemical typhoid vaccine in controlled field trials.

作者信息

Hejfets L B, Levina L A, Salmin L V, Antonova A A, Segal L S, Kuzminova M L, Slavina K M, Vasileva A V

出版信息

J Hyg Epidemiol Microbiol Immunol. 1976;21(3):292-9.

Abstract

A total of 3 controlled field trials were carried out. One of them (1963) showed that aerosol chemical typhoid vaccine did not protect vaccinated subjects from the disease. Two other tests (1964 and 1965) assessing the effectivity of killed orally administered typhoid vaccine revealed a short term (up to 3 months) protective effect expressed by an effectivity coefficient of 45%, fiducial limits being 8-70%. In the assessment of oral paratyphoid B vaccine, the difference in morbidity in the experimental and control groups was statistically insignificant due to a small number of cases of disease.

摘要

总共进行了3项对照现场试验。其中一项试验（1963年）表明，气溶胶化学伤寒疫苗不能保护接种者免受该疾病感染。另外两项试验（1964年和1965年）评估了口服伤寒灭活疫苗的有效性，结果显示出短期（长达3个月）的保护作用，有效系数为45%，置信区间为8%-70%。在评估口服副伤寒B疫苗时，由于发病病例数较少，实验组和对照组的发病率差异无统计学意义。