McDonough P G, Ellegood J O, Byrd J R, Mahesh V B
Obstet Gynecol. 1976 Mar;47(3):351-5.
Determinations of multiple steroids were made on ovarian and peripheral blood in a 46,XY patient with bilateral gonadoblastoma. The right gonadoblastoma had undergone complete calcific ablation. The principal viable cellular elements in the left gonadoblastoma were Leydig cells. Except for a borderline increase over peripheral levels of estradiol, the degenerated right tumor mass showed no evidence of endocrine activity. Venous blood emanating from the left cellular gonadoblastoma exhibited significant elevations of testosterone, progesterone, and estradiol as compared to peripheral blood. Viable sex cord elements were present in the left tumor mass but did not exhibit sufficient steroid activity to have demonstrable clinical manifestations.
对一名患有双侧性母细胞瘤的46,XY患者的卵巢和外周血进行了多种类固醇测定。右侧性母细胞瘤已完全钙化消融。左侧性母细胞瘤中的主要存活细胞成分是睾丸间质细胞。除了雌二醇水平比外周水平略有升高外，退化的右侧肿瘤块没有内分泌活性的迹象。与外周血相比，来自左侧有细胞活性的性母细胞瘤的静脉血中睾酮、孕酮和雌二醇水平显著升高。左侧肿瘤块中存在有活性的性索成分，但未表现出足以产生明显临床表现的类固醇活性。
