两名慢性丙型肝炎患者接受干扰素和利巴韦林短疗程治疗后的持续病毒学应答 - Suppr

Sustained virological response after a short course of treatment with interferon and ribavirin in two chronic hepatitis C patients.

作者信息

Nousbaum Jean-Baptiste, Cadranel Jean-François, Savary Olivier, Legrand Marie-Christine, Dumouchel Patrice, Gouérou Hervé

出版信息

J Hepatol. 2003 Oct;39(4):655-6. doi: 10.1016/s0168-8278(03)00403-3.

DOI:10.1016/s0168-8278(03)00403-3

PMID:12971981

Abstract

摘要

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Sustained virological response after a short course of treatment with interferon and ribavirin in two chronic hepatitis C patients.两名慢性丙型肝炎患者接受干扰素和利巴韦林短疗程治疗后的持续病毒学应答

J Hepatol. 2003 Oct;39(4):655-6. doi: 10.1016/s0168-8278(03)00403-3.

Evaluation of long-term efficacy of interferon alpha-2b and ribavirin in combination in naive patients with chronic hepatitis C: an Italian multicenter experience. Ribavirin-Interferon in Chronic Hepatitis Italian Group Investigators.

J Hepatol. 2000 Sep;33(3):448-55. doi: 10.1016/s0168-8278(00)80281-0.

Adding ribavirin to interferon alpha-2b for chronic hepatitis C infection increased virological response and nausea.对于慢性丙型肝炎感染，在干扰素α-2b基础上加用利巴韦林可提高病毒学应答率，但会增加恶心症状。

Gut. 1998 Nov;43(5):602. doi: 10.1136/gut.43.5.602.

Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients.胰岛素抵抗会损害慢性丙型肝炎患者对聚乙二醇干扰素加利巴韦林的持续应答率。

Gastroenterology. 2005 Mar;128(3):636-41. doi: 10.1053/j.gastro.2004.12.049.

Effect of combined interferon-alpha induction therapy and ribavirin on chronic hepatitis C virus infection: a randomized multicentre study.

Scand J Gastroenterol. 2002 Feb;37(2):226-32. doi: 10.1080/003655202753416920.

Early addition of ribavirin to interferon in chronic hepatitis C not responsive to interferon monotherapy.

J Hepatol. 2000 Sep;33(3):463-8. doi: 10.1016/s0168-8278(00)80283-4.

Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group.干扰素α-2b联合或不联合利巴韦林治疗慢性丙型肝炎的随机、双盲、安慰剂对照试验。瑞典研究小组。

Lancet. 1998 Jan 10;351(9096):83-7. doi: 10.1016/s0140-6736(97)06088-1.

Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT).干扰素α2b联合利巴韦林治疗48周或24周与干扰素α2b联合安慰剂治疗48周用于慢性丙型肝炎病毒感染的随机试验。国际肝炎介入治疗组（IHIT）。

Lancet. 1998 Oct 31;352(9138):1426-32. doi: 10.1016/s0140-6736(98)07124-4.

Pharmacokinetics of ribavirin in combined interferon-alpha 2b and ribavirin therapy for chronic hepatitis C virus infection.利巴韦林在联合α-2b干扰素和利巴韦林治疗慢性丙型肝炎病毒感染中的药代动力学

Br J Clin Pharmacol. 2003 Apr;55(4):360-7. doi: 10.1046/j.1365-2125.2003.01780.x.

Interferon-alpha-2b plus ribavirin: a review of its use in the management of chronic hepatitis C.干扰素-α-2b 加利巴韦林：关于其在慢性丙型肝炎治疗中应用的综述

Drugs. 2002;62(3):507-56. doi: 10.2165/00003495-200262030-00009.

引用本文的文献

Short versus standard treatment with pegylated interferon alfa-2A plus ribavirin in patients with hepatitis C virus genotype 2 or 3: the cleo trial.聚乙二醇干扰素 alfa-2A 联合利巴韦林与标准疗程治疗丙型肝炎病毒基因型 2 或 3 患者的比较：CLEO 试验。

BMC Gastroenterol. 2010 Feb 19;10:21. doi: 10.1186/1471-230X-10-21.

Short-term therapy for patients with hepatitis C virus genotype 2 or 3 infection.丙型肝炎病毒2型或3型感染患者的短期治疗。

Drugs. 2006;66(14):1807-15. doi: 10.2165/00003495-200666140-00003.

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Sustained virological response after a short course of treatment with interferon and ribavirin in two chronic hepatitis C patients.

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