Koh Kwang Kon, Ahn Jeong Yeal, Choi Yu Mi, Han Seung Hwan, Kim Dae Sung, Kim Hyung Sik, Ahn Tae Hoon, Choi In Suck, Shin Eak Kyun
Vascular Medicine and Atherosclerosis Unit, Department of Cardiology, Gil Heart Center, Gachon Medical School, 1198 Kuwol-dong, Namdong-gu, Incheon, Korea.
Am J Cardiol. 2003 Sep 15;92(6):708-10. doi: 10.1016/s0002-9149(03)00832-4.
We administered a step I diet to 50 hypercholesterolemic patients with coronary artery disease during 12 weeks. Compared with baseline, the step I diet significantly changed lipoprotein levels, significantly improved the percent flow-mediated dilation response to hyperemia by 32 +/- 7% (p <0.001), increased plasma levels of nitrate by 45 +/- 12% (p = 0.013), and lowered plasma levels of malondialdehyde by 7 +/- 4% (p = 0.011). However, the step I diet did not significantly change serologic markers of inflammation, plaque stability, and thrombosis. Step I diet therapy improved endothelium-dependent vasodilation with an increase in plasma nitrogen oxide and a decrease in oxidant stress in hypercholesterolemic patients with coronary artery disease.
我们在12周内对50名患有冠状动脉疾病的高胆固醇血症患者实施了I期饮食方案。与基线相比，I期饮食方案显著改变了脂蛋白水平，使血流介导的充血扩张反应百分比显著提高了32±7%（p<0.001），血浆硝酸盐水平升高了45±12%（p = 0.013），血浆丙二醛水平降低了7±4%（p = 0.011）。然而，I期饮食方案并未显著改变炎症、斑块稳定性和血栓形成的血清学标志物。I期饮食疗法改善了冠状动脉疾病高胆固醇血症患者的内皮依赖性血管舒张功能，同时血浆一氧化氮增加，氧化应激降低。
