Wu Yuzhou, Li Shuqin, Cui Wei, Zu Xiuguang, Wang Fengfei, Du Jun
Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
Planta Med. 2007 Jun;73(7):624-8. doi: 10.1055/s-2007-981536. Epub 2007 Jun 13.
Ginkgo biloba extract (GBE) has well-documented cardioprotective effects on coronary flow and positive effects on vasodilation through endothelium-derived nitric oxide in experimental animals, but these impacts in patients with coronary artery disease (CAD) have not yet been investigated. We designed this study to test the effects of GBE on distal left anterior descending coronary artery (LAD) blood flow and endothelium-dependent brachial artery flow-mediated dilation (FMD) in patients with CAD. Eighty CAD patients were randomly assigned to either GBE or saline (control) groups. LAD blood flow and brachial artery FMD were measured non-invasively using high-resolution ultrasound before and after intravenous administration of GBE or saline. GBE significantly increased LAD blood flow in maximal diastolic peak velocity (MDPV), maximal systolic peak velocity (MSPV) and diastolic time velocity integral (DTVI) compared with the control group (16.14 +/- 10.93 % vs. 0.28 +/- 2.14 %, 9.14 +/- 8.23 % vs. 0.79 +/- 2.56 %, and 15.23 +/- 7.28 % vs. 0.42 +/- 2.43 %, respectively, p < 0.01). Brachial artery FMD was also increased by 69.75 % (from 3.95 +/- 1.49 % to 6.55 +/- 2.51 %, p < 0.01). A linear correlation was found between the percentage changes in MDPV, MSPV, or DTVI of LAD blood flow and the percentage change in brachial artery FMD following treatment with GBE (r = 0.612, 0.486, or 0.521, respectively, p < 0.01). In summary, our data demonstrate that GBE treatment in CAD patients leads to an increase of LAD blood flow in MDPV, MSPV and DTVI, and the increase response might relate to the improved endothelium-dependent vasodilatory capacity. CAD: coronary artery disease DTVI: diastolic time velocity integral FMD: flow-mediated dilation GBE: GINKGO BILOBA extract LAD: distal left anterior descending coronary artery MDPV: maximal diastolic peak velocity MSPV: maximal systolic peak velocity NO: nitric oxide TTDE: transthoracic Doppler echocardiography.
银杏叶提取物（GBE）对实验动物的冠状动脉血流具有充分记录的心脏保护作用，并通过内皮源性一氧化氮对血管舒张有积极作用，但这些作用在冠状动脉疾病（CAD）患者中的影响尚未得到研究。我们设计本研究以测试GBE对CAD患者左前降支冠状动脉（LAD）远端血流和内皮依赖性肱动脉血流介导的舒张功能（FMD）的影响。80例CAD患者被随机分为GBE组或生理盐水（对照组）。在静脉注射GBE或生理盐水前后，使用高分辨率超声非侵入性测量LAD血流和肱动脉FMD。与对照组相比，GBE显著增加了LAD血流的最大舒张期峰值速度（MDPV）、最大收缩期峰值速度（MSPV）和舒张期时间速度积分（DTVI）（分别为16.14±10.93%对0.28±2.14%，9.14±8.23%对0.79±2.56%，以及15.23±7.28%对0.42±2.43%，p<0.01）。肱动脉FMD也增加了69.75%（从3.95±1.49%增至6.55±2.51%，p<0.01）。在GBE治疗后，LAD血流的MDPV、MSPV或DTVI的百分比变化与肱动脉FMD的百分比变化之间发现线性相关性（r分别为0.612、0.486或0.521，p<0.01）。总之，我们的数据表明，CAD患者接受GBE治疗可导致LAD血流的MDPV、MSPV和DTVI增加，且这种增加反应可能与内皮依赖性血管舒张能力的改善有关。CAD：冠状动脉疾病；DTVI：舒张期时间速度积分；FMD：血流介导的舒张功能；GBE：银杏叶提取物；LAD：左前降支冠状动脉远端；MDPV：最大舒张期峰值速度；MSPV：最大收缩期峰值速度；NO：一氧化氮；TTDE：经胸多普勒超声心动图。
