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辛伐他汀与安慰剂对老年外周动脉疾病患者治疗6个月及1年后直至间歇性跛行发作的跑步机运动时间的影响。

Effect of simvastatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral arterial disease at six months and at one year after treatment.

作者信息

Aronow Wilbert S, Nayak Devraj, Woodworth Steven, Ahn Chul

机构信息

Department of Medicine, Cardiology Division, Westchester Medical Center/New York Medical College, Macy Pavilion Room 138, Valhalla, NY 10595, USA.

出版信息

Am J Cardiol. 2003 Sep 15;92(6):711-2. doi: 10.1016/s0002-9149(03)00833-6.

DOI:10.1016/s0002-9149(03)00833-6
PMID:12972114
Abstract

Simvastatin significantly increased treadmill exercise time until onset of intermittent claudication from baseline by 54 seconds (a 24% increase, p <0.0001) at 6 months after treatment and by 95 seconds (a 42% increase, p <0.0001) at 1 year after treatment. At 6 months and 1 year after treatment with placebo, treadmill exercise time until onset of intermittent claudication was not significantly different from baseline exercise time.

摘要

辛伐他汀显著增加了直至间歇性跛行发作的跑步机运动时间，治疗后6个月时较基线增加了54秒（增加24%，p<0.0001），治疗后1年时增加了95秒（增加42%，p<0.0001）。使用安慰剂治疗后6个月和1年时，直至间歇性跛行发作的跑步机运动时间与基线运动时间无显著差异。

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