Aiman U, Haseen M A, Beg M H, Khan R A, Siddiqui F A, Alam I
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh-202 002, India.
Department of Cardiothoracic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh-202 002, India.
Indian J Pharm Sci. 2014 Nov-Dec;76(6):504-9.
Peripheral arterial disease, being a manifestation of systemic atherosclerosis, carries a high risk of adverse cardiovascular events. Secondary medical prevention therapies of same magnitude as that for coronary artery disease are recommended for peripheral arterial disease patients also. Available evidence indicates that this condition commonly remains underdiagnosed and undertreated. There is lack of any report about management of these patients in India. The objectives of the present study were to characterize the atherosclerotic risk factor profile and pattern of drug prescription for patients of peripheral arterial disease at a tertiary care teaching hospital and to compare this management with standard guidelines. Data were collected from prescriptions of patients attending cardiothoracic and vascular surgery outpatient department with diagnosis of atherosclerotic peripheral arterial disease from July 2012 to Jun 2013. One hundred twenty prescriptions were analysed. The mean age (±SD) of patients was 53±7.18 years and 23.3% were females. History of smoking, either past or present, was present in 91.6% patients. History of ischemic heart disease was present in 25%, while 26.7% patients were diabetic. Mean number of cardiovascular risk factors was 2.6. The percentage of eligible patients who were receiving a particular drug was 100% for aspirin and statins, 48.3% for angiotensin converting enzyme inhibitors, 46.7% for beta blockers and 66.7% for cilostazol. The vascular surgeons of this centre are using antiplatelet agents and statins adequately for peripheral arterial disease. The prescription of angiotensin converting enzyme inhibitors, beta blockers and cilostazol is low. Exercise therapy and smoking cessation need more attention.
外周动脉疾病作为全身性动脉粥样硬化的一种表现形式，具有发生不良心血管事件的高风险。对于外周动脉疾病患者，也推荐采用与冠状动脉疾病同等强度的二级医疗预防疗法。现有证据表明，这种疾病通常仍未得到充分诊断和治疗。在印度，尚无关于这些患者管理的任何报告。本研究的目的是描述一家三级医疗教学医院外周动脉疾病患者的动脉粥样硬化危险因素概况和药物处方模式，并将这种管理与标准指南进行比较。收集了2012年7月至2013年6月在心胸血管外科门诊就诊且诊断为动脉粥样硬化性外周动脉疾病患者的处方数据。共分析了120份处方。患者的平均年龄（±标准差）为53±7.18岁，女性占23.3%。91.6%的患者有吸烟史，无论是过去还是现在。25%的患者有缺血性心脏病史，26.7%的患者患有糖尿病。心血管危险因素的平均数量为2.6个。接受特定药物治疗的符合条件患者的百分比分别为：阿司匹林和他汀类药物为100%，血管紧张素转换酶抑制剂为48.3%，β受体阻滞剂为46.7%，西洛他唑为66.7%。该中心的血管外科医生对外周动脉疾病患者充分使用了抗血小板药物和他汀类药物。血管紧张素转换酶抑制剂、β受体阻滞剂和西洛他唑的处方量较低。运动疗法和戒烟需要更多关注。
