病毒钾通道Kcv：结构与功能特征

The viral potassium channel Kcv: structural and functional features.

作者信息

Gazzarrini Sabrina, Severino Maria, Lombardi Mara, Morandi Marzia, DiFrancesco Dario, Van Etten James L, Thiel Gerhard, Moroni Anna

机构信息

Department of Biology, CNR-IBF Unità di Milano, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.

出版信息

FEBS Lett. 2003 Sep 18;552(1):12-6. doi: 10.1016/s0014-5793(03)00777-4.

DOI:10.1016/s0014-5793(03)00777-4

PMID:12972145

Abstract

The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.

摘要

小球藻病毒PBCV-1是首个被发现编码功能性钾通道蛋白（Kcv）的病毒。Kcv很小（94个氨基酸），基本由所有已知钾通道孔区典型的M1-P-M2（膜-孔-膜）模块组成。Kcv在三种异源系统中形成功能性通道。这篇简短的综述讨论了Kcv的门控、通透性和调节特性，并将它们与细菌和哺乳动物钾通道的特性进行了比较。