展示病毒编码蛋白的内在离子通道活性。

Demonstrating the intrinsic ion channel activity of virally encoded proteins.

作者信息

Kelly Marie L, Cook James A, Brown-Augsburger Patricia, Heinz Beverly A, Smith Michele C, Pinto Lawrence H

机构信息

Department of Physiology, Wayne State Medical School, Detroit, MI 48201, USA.

出版信息

FEBS Lett. 2003 Sep 18;552(1):61-7. doi: 10.1016/s0014-5793(03)00851-2.

DOI:10.1016/s0014-5793(03)00851-2

PMID:12972153

Abstract

This review summarizes the types of evidence that can be invoked in order to demonstrate that a virally encoded protein possesses ion channel activity that is intrinsic to the life cycle of the virus. Ion channel activity has been proposed to be a key step in the life cycle of influenza virus, and the protein responsible for this activity has been proposed to be the M2 protein encoded by the virus. This review contrasts the evidence supporting the conclusion that the A/M2 protein of influenza A virus has intrinsic ion channel activity with the evidence that the 3AB protein encoded by the human rhinovirus possesses intrinsic ion channel activity.

摘要

本综述总结了可用于证明病毒编码蛋白具有病毒生命周期内在离子通道活性的各类证据。离子通道活性被认为是流感病毒生命周期中的关键步骤，而负责该活性的蛋白被认为是病毒编码的M2蛋白。本综述对比了支持甲型流感病毒A/M2蛋白具有内在离子通道活性这一结论的证据，以及人鼻病毒编码的3AB蛋白具有内在离子通道活性的证据。