Gobbelé René, Waberski Till Dino, Thyerlei Dinah, Thissen Melanie, Darvas Felix, Klostermann Fabian, Curio Gabriel, Buchner Helmut
Department of Neurology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Neurosci Lett. 2003 Oct 23;350(2):97-100. doi: 10.1016/s0304-3940(03)00877-2.
To identify the possibly divergent impact on early and late high-frequency oscillations (HFOs) in human somatosensory evoked potentials (SEPs), we have studied motor interference effects on the HFOs, and the relevance of such effects for the controversy concerning their origins. While the late HFO is thought to be generated in the somatosensory cortex, there is an ongoing discussion whether the early burst is of cortical or subcortical origin. Movements of the index finger were performed in parallel with median nerve SEP recordings. The intracortically generated N20-SEP and the late HFO were attenuated by the motor task, while the brainstem low-frequency P14-SEP and the early HFO remained unaffected. These differing effects are consistent with a generation of the early HFOs by cortical presynaptic activity in terminals of the thalamocortical projection, and confirm a postsynaptic intracortical origin of the late burst subcomponent.
为了确定对人类体感诱发电位（SEP）中早期和晚期高频振荡（HFO）可能存在的不同影响，我们研究了运动干扰对HFO的影响，以及此类影响与关于其起源的争议之间的相关性。虽然晚期HFO被认为是在体感皮层产生的，但对于早期爆发是皮层起源还是皮层下起源仍在进行讨论。在记录正中神经SEP的同时，进行食指运动。皮层内产生的N20-SEP和晚期HFO因运动任务而衰减，而脑干低频P14-SEP和早期HFO则不受影响。这些不同的影响与丘脑皮质投射终末的皮层突触前活动产生早期HFO一致，并证实了晚期爆发子成分的突触后皮层内起源。
