Mogi K, Yonezawa T, Chen D-S, Li J-Y, Sawasaki T, Nishihara M
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo 113-8657, Japan.
Domest Anim Endocrinol. 2003 Aug;25(2):175-82. doi: 10.1016/s0739-7240(03)00056-0.
Feeding behavior is regulated by neural signals in the hypothalamus, but secretory activities of these signals in vivo and their relationship with spontaneous feeding remain to be solved. In the present study, we investigated the correlation between neuropeptide Y (NPY) and somatostatin (SRIF) profiles in cerebrospinal fluid (CSF) and spontaneous feeding behavior in goats. CSF samples were collected every 15 min for 8 h from the third ventricle and feeding behavior was observed throughout the experimental period. The spontaneous feeding behavior, the mean duration of which was 58 min, occurred with an interval of 146 min. NPY in the CSF fluctuated in an episodic fashion with a 145 min interval. Each NPY episode was followed by spontaneous feeding with a time lag of 24 min. SRIF levels in CSF changed more frequently in a pulsatile manner and were related to neither NPY profiles nor feeding behavior. These results suggest that NPY, but not SRIF, is a physiological signal to drive feeding in goats.
摄食行为受下丘脑神经信号的调节，但这些信号在体内的分泌活动及其与自发摄食的关系仍有待解决。在本研究中，我们调查了山羊脑脊液（CSF）中神经肽Y（NPY）和生长抑素（SRIF）水平与自发摄食行为之间的相关性。从第三脑室每15分钟采集一次CSF样本，持续8小时，并在整个实验期间观察摄食行为。自发摄食行为的平均持续时间为58分钟，间隔为146分钟。CSF中的NPY以间歇性方式波动，间隔为145分钟。每次NPY发作后24分钟会出现自发摄食。CSF中SRIF水平以脉冲方式变化更频繁，且与NPY水平和摄食行为均无关。这些结果表明，NPY而非SRIF是驱动山羊摄食的生理信号。
