[Effects of sodium valproate in a model of penicillin epilepsy in rats].

Effects of sodium valproate in penicillin-induced epilepsy in rats have been described. To one group of rats penicillin was given I.P. (10(6) IU/kg) and to the another one it was given I.C. (100 IU). After development of grand mal sodium valproate was given I.P. to all rats except the control group. In the group receiving I.C. penicillin it has come to cessation of individual discharges and grand mal after valproate application. In the group receiving I.P. penicillin, valproate prevented only grand mal while individual discharges remained. It is obvious that much higher doses of penicillin are necessary for the development of the epileptic model if penicillin is given I.P.