日本男性的心肺适能与癌症死亡率：一项前瞻性研究。
Cardiorespiratory fitness and cancer mortality in Japanese men: a prospective study.
作者信息
Sawada Susumu S, Muto Takashi, Tanaka Hiroaki, Lee I-Min, Paffenbarger Ralph S, Shindo Munehiro, Blair Steven N
机构信息
Tokyo Gas Health Promotion Center, Tokyo, Japan.
出版信息
Med Sci Sports Exerc. 2003 Sep;35(9):1546-50. doi: 10.1249/01.MSS.0000084525.06473.8E.
PURPOSE
Limited data are available on the relationship between cardiorespiratory fitness and cancer mortality. We evaluated the cardiorespiratory fitness and risk of cancer mortality in Japanese men.
METHODS
A total of 9039 men (19-59 yr) who were given a submaximal exercise test and a health examination between 1982 and 1988 and were followed for mortality up to 1999. Cardiorespiratory fitness was measured using a cycle ergometer test, and maximal oxygen uptake was estimated.
RESULTS
The mean follow-up period was slightly more than 16 yr, producing a total of 148,491 person-years of observation. There were 231 deaths, with 123 deaths due to cancer. Relative risk (RR) and 95% confidence interval (95%CI) for cancer mortality were obtained using the Cox proportional hazards model. Taking into consideration age, systolic blood pressure, body mass index, smoking habit, and alcohol habit and using the lowest physical fitness group as the reference, the RR (95% CI) for increasing quartiles of fitness were 0.75(0.48-1.16), 0.43(0.25-0.74) and 0.41(0.23-0.74); P < 0.001 for trend.
CONCLUSION
Low cardiorespiratory fitness is associated with cancer mortality in Japanese men.
目的
关于心肺适能与癌症死亡率之间的关系，现有数据有限。我们评估了日本男性的心肺适能及癌症死亡风险。
方法
共有9039名男性（19 - 59岁）在1982年至1988年间接受了次极量运动测试和健康检查，并随访至1999年的死亡情况。使用自行车测力计测试测量心肺适能，并估算最大摄氧量。
结果
平均随访期略超过16年，总计观察148,491人年。共有231例死亡，其中123例死于癌症。使用Cox比例风险模型获得癌症死亡率的相对风险（RR）和95%置信区间（95%CI）。考虑到年龄、收缩压、体重指数、吸烟习惯和饮酒习惯，并以体能最低组作为参照，体能四分位数增加时的RR（95%CI）分别为0.75（0.48 - 1.16）、0.43（0.25 - 0.74）和0.41（0.23 - 0.74）；趋势P < 0.001。
结论
心肺适能低与日本男性的癌症死亡率相关。
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