Ohno Yoshiharu, Sugimura Kazuro, Hatabu Hiroto
Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Top Magn Reson Imaging. 2003 Jun;14(3):237-43. doi: 10.1097/00002142-200306000-00004.
Oxygen-enhanced magnetic resonance (MR) ventilation imaging is a new technique, and the full extent of its physiologic significance has not been elucidated. This review article includes (1) theory of oxygen enhancement; (2) respiratory physiology; (3) oxygen-enhanced MR imaging (MRI) sequence design; (4) basic study of oxygen-enhanced MRI in animal models and humans; (5) clinical study of oxygen-enhanced MRI; and (6) merits and demerits of the technique in comparison with hyperpolarized noble gas MR ventilation imaging. Oxygen-enhanced MRI provides not only ventilation-related information but also respiration-related information. Although application of oxygen-enhanced MR ventilation imaging to patients with pulmonary diseases has been limited, oxygen-enhanced MRI offers the possibility of demonstrating regional pulmonary function and substituting for nuclear medicine ventilation-perfusion study, when combined with MR perfusion imaging. We believe that further basic studies and clinical applications of this new technique will define the real significance of oxygen-enhanced MR ventilation imaging in the future of pulmonary functional imaging and its usefulness for diagnostic radiology.
氧增强磁共振（MR）通气成像是一项新技术，其生理意义的全貌尚未阐明。这篇综述文章包括：（1）氧增强理论；（2）呼吸生理学；（3）氧增强MR成像（MRI）序列设计；（4）动物模型和人体中氧增强MRI的基础研究；（5）氧增强MRI的临床研究；以及（6）与超极化惰性气体MR通气成像相比该技术的优缺点。氧增强MRI不仅提供与通气相关的信息，还提供与呼吸相关的信息。尽管氧增强MR通气成像在肺部疾病患者中的应用有限，但当与MR灌注成像结合时，氧增强MRI提供了显示局部肺功能并替代核医学通气灌注研究的可能性。我们相信，这项新技术的进一步基础研究和临床应用将在未来肺功能成像中明确氧增强MR通气成像的真正意义及其对诊断放射学的有用性。
