Eskelinen Tuomo, Niiranen Juha, Juutilainen Jukka
Department of Environmental Sciences, University of Kuopio, Finland.
J Expo Anal Environ Epidemiol. 2003 Sep;13(5):372-7. doi: 10.1038/sj.jea.7500283.
In this study, we introduced and tested a new approach to characterize residential magnetic field (MF) exposure. Short-term 20-min MF measurements were obtained by a person who carried out instantaneous spot measurements in residences. Compared to spot measurements, the 20-min measurement could potentially improve exposure assessment, because it contains information of temporal variations of MF, which have been suggested as biologically important characteristics of MF exposure. We have used this new exposure assessment method on a study of maternal MF exposure and reproductive outcomes. To validate the new method, the exposure of 30 subjects was measured with a more accurate "gold standard" method (24 h personal exposure measurements). The measures of validity used were the Spearman correlation coefficient (r), sensitivity, and specificity. We evaluated the validity of the 20-min measurements for estimating several different exposure metrics for the entire 24 h measurement period or for the hours spent at home: arithmetic mean, median, percentage of time above 0.15 microT, standard deviation, rate of change metric, standardized rate of change metric, constant field metric, and three metrics for the occurrence of high-peak exposures. The 20-min measurement was modestly associated with standard deviation and the rate of change metric, but gave very little information of other metrics of temporal variation. The 20-min measurement can also be used for assessing exposure metrics such as arithmetic mean and median, but it does not seem to offer any advantages compared to traditional 'spot' measurements. The 20-min measurement was not useful for assessing occurrence of high-peak exposures. We conclude that the 20-min measurement is useful for estimating some aspects of MF temporal variability.
在本研究中,我们引入并测试了一种表征住宅磁场(MF)暴露的新方法。由一名在住宅中进行即时现场测量的人员获取20分钟的短期MF测量值。与现场测量相比,20分钟测量可能会改善暴露评估,因为它包含MF时间变化的信息,而MF时间变化已被认为是MF暴露的重要生物学特征。我们已将这种新的暴露评估方法用于一项关于孕妇MF暴露与生殖结局的研究。为验证该新方法,用一种更精确的“金标准”方法(24小时个人暴露测量)测量了30名受试者的暴露情况。所使用的效度指标为斯皮尔曼相关系数(r)、灵敏度和特异性。我们评估了20分钟测量值对于估计整个24小时测量期或在家中度过的时间内几种不同暴露指标的效度:算术平均值、中位数、高于0.15微特斯拉的时间百分比、标准差、变化率指标、标准化变化率指标、恒定场指标以及三种高峰暴露发生指标。20分钟测量值与标准差和变化率指标有适度关联,但对于其他时间变化指标提供的信息很少。20分钟测量值也可用于评估算术平均值和中位数等暴露指标,但与传统的“现场”测量相比似乎没有任何优势。20分钟测量值对于评估高峰暴露的发生情况并无用处。我们得出结论,20分钟测量值对于估计MF时间变异性的某些方面是有用的。