Bernecker Oliver Y, del Monte Federica, Hajjar Roger J
Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Semin Thorac Cardiovasc Surg. 2003 Jul;15(3):268-76. doi: 10.1016/s1043-0679(03)70006-9.
The knowledge of molecular mechanisms indicated in cardiac dysfunction has increased dramatically over the last decade and yields considerable potential for new treatment options in heart failure. Alterations in intracellular calcium signaling play a crucial role in the pathophysiology of heart failure, and in recent years, somatic gene transfer has been identified as an important tool to help understand the relative contribution of specific calcium-handling proteins in heart failure. This article reviews recent advances in gene delivery techniques aimed at global myocardial transfection and discusses molecular therapeutic targets identified within intracellular calcium signaling pathways in heart failure.
在过去十年中，关于心脏功能障碍所涉及分子机制的知识有了显著增长，为心力衰竭的新治疗方案带来了巨大潜力。细胞内钙信号的改变在心力衰竭的病理生理学中起着关键作用，近年来，体细胞基因转移已被确认为一种重要工具，有助于了解特定钙处理蛋白在心力衰竭中的相对作用。本文综述了旨在实现全心肌转染的基因递送技术的最新进展，并讨论了在心力衰竭细胞内钙信号通路中确定的分子治疗靶点。
