Calò Carla Maria, Varesi Laurent, Memmi Marc, Moral Pedro, Vona Giuseppe
Department of Experimental Biology, Section of Anthropological Sciences, University of Cagliari, Monserrato, Italy.
Coll Antropol. 2003 Jun;27(1):105-15.
Apolipoprotein (a) is a component of lipoprotein (a). Several studies have shown the association between risk of coronary heart diseases and the size of apo(a) isoforms, although this issue is still controversial. Recent researches focused the attention on the pentanucleotide (TTTTA), highlighting a statistical correlation between low Lp(a) levels and high repeat numbers. In the present paper we studied the distribution of the apo(a) pentanucleotide polymorphism among populations from Corsica, and we then compared it with other populations from Europe, Africa and Asia. The results stressed out the usefulness of these markers in population genetics analysis. We later investigated the possible association of the apo(a) pentanucleotide polymorphism with serum lipid levels in two samples from Corsica (France): one comprises patients or individuals with high risk of future coronary heart disease and the other is a control sample. No significant differences between the two groups have been found, but the analysis of variance showed a significant association between different genotypes and cholesterol and LDL serum levels.
载脂蛋白(a)是脂蛋白(a)的一个组成部分。多项研究表明冠心病风险与载脂蛋白(a)异构体大小之间存在关联，尽管这个问题仍存在争议。最近的研究将注意力集中在五核苷酸(TTTTA)上，突出了低脂蛋白(a)水平与高重复次数之间的统计相关性。在本文中，我们研究了科西嘉岛人群中载脂蛋白(a)五核苷酸多态性的分布，然后将其与来自欧洲、非洲和亚洲的其他人群进行了比较。结果强调了这些标记在群体遗传学分析中的有用性。随后，我们在来自法国科西嘉岛的两个样本中研究了载脂蛋白(a)五核苷酸多态性与血脂水平之间的可能关联：一个样本包括未来患冠心病风险高的患者或个体，另一个是对照样本。两组之间未发现显著差异，但方差分析显示不同基因型与血清胆固醇和低密度脂蛋白水平之间存在显著关联。
