Husedzinović Ino, Tonković Dinko, Barisin Stjepan, Bradić Nikola, Gasparović Stojanka
Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Hospital Dubrava, Zagreb, Croatia.
Coll Antropol. 2003 Jun;27(1):205-12.
The aim of the study was to compare the effect of sevoflurane and propofol anesthesia on myocardial contractility during laparotomic cholecystectomy using transesophageal echo-Doppler. In the study, 40 patients were randomized into two groups, depending on whether they received sevoflurane or propofol anesthesia. Heart rate, cardiac index, stroke volume, left ventricular ejection time and acceleration were measured 10 minutes after induction of anesthesia, 1 minute and 25 minutes after incision. The results were analyzed using paired t-test and ANOVA. Significantly lower values were found for all parameters after the initial measurement (p < 0.05). In the sevoflurane group, stroke volume decreased from 66 +/- 6.2 ml/beat to 65 +/- 6.4 ml/beat and to 63 +/- 5.6 ml/beat 1 minute and 25 minutes after incision respectively. In the propofol group changes were from 64 ml/beat to 58 +/- 10.5 ml/beat to 58 +/- 8.6 ml/beat. Stroke volume was significantly higher in the sevoflurane than in the propofol group (p < 0.05). Sevoflurane anesthesia allows a better hemodynamic stability during laparotomic cholecystectomy.
本研究的目的是使用经食管超声多普勒比较七氟醚和丙泊酚麻醉对开腹胆囊切除术中心肌收缩力的影响。在该研究中，40例患者根据接受七氟醚或丙泊酚麻醉被随机分为两组。在麻醉诱导后10分钟、切口后1分钟和25分钟测量心率、心脏指数、每搏量、左心室射血时间和加速度。结果采用配对t检验和方差分析进行分析。初始测量后所有参数的值均显著降低（p < 0.05）。在七氟醚组中，每搏量在切口后1分钟和25分钟分别从66±6.2 ml/次搏动降至65±6.4 ml/次搏动和63±5.6 ml/次搏动。在丙泊酚组中，变化分别从64 ml/次搏动降至58±10.5 ml/次搏动和58±8.6 ml/次搏动。七氟醚组的每搏量显著高于丙泊酚组（p < 0.05）。七氟醚麻醉在开腹胆囊切除术中能实现更好的血流动力学稳定性。
