埃博拉病毒：从发现到疫苗

Ebola virus: from discovery to vaccine.

作者信息

Feldmann Heinz, Jones Steven, Klenk Hans-Dieter, Schnittler Hans-Joachim

机构信息

Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.

出版信息

Nat Rev Immunol. 2003 Aug;3(8):677-85. doi: 10.1038/nri1154.

DOI:10.1038/nri1154

PMID:12974482

Abstract

Ebola virus, being highly pathogenic for humans and non-human primates and the subject of former weapons programmes, is now one of the most feared pathogens worldwide. In addition, the lack of pre- and post-exposure interventions makes the development of rapid diagnostics, new antiviral agents and protective vaccines a priority for many nations. Further insight into the ecology, immunology and pathogenesis of Ebola virus will promote the delivery of these urgently required tools.

摘要

埃博拉病毒对人类和非人类灵长类动物具有高度致病性，并且曾是武器计划的研究对象，如今是全球最令人恐惧的病原体之一。此外，由于缺乏暴露前和暴露后干预措施，开发快速诊断方法、新型抗病毒药物和保护性疫苗成为许多国家的优先事项。对埃博拉病毒的生态学、免疫学和发病机制的进一步了解将推动这些急需工具的提供。