Sundquist Malin, Johansson Cecilia, Wick Mary Jo
Department of Clinical Immunology, Göteborg University, Sweden.
APMIS. 2003 Jul-Aug;111(7-8):715-24. doi: 10.1034/j.1600-0463.2003.11107804.x.
Models of infection have provided important insight into the function of dendritic cells (DC) in vivo. Several microbial products induce DC maturation via Toll-like receptors, a process that is crucial for the ability of DC to initiate adaptive immune responses. Splenic DC have also been shown to produce IL-12 during infection in vivo. This DC-derived IL-12 might be important to skew T cell responses towards Th1. Microbial infections also induce changes in the DC populations of lymphoid organs, often in a subset-specific manner, manifested as an accumulation and redistribution of DC. Furthermore, data are emerging pointing at an absolute requirement of DC in priming of naïve T cells in vivo.
感染模型为深入了解树突状细胞（DC）在体内的功能提供了重要线索。几种微生物产物通过Toll样受体诱导DC成熟，这一过程对于DC启动适应性免疫反应的能力至关重要。脾脏DC在体内感染期间也被证明能产生IL-12。这种DC来源的IL-12可能对使T细胞反应偏向Th1很重要。微生物感染还会诱导淋巴器官中DC群体发生变化，通常以亚群特异性方式表现为DC的积累和重新分布。此外，越来越多的数据表明，DC在体内启动初始T细胞方面是绝对必需的。
