Licht R W, Vestergaard P, Kessing L V, Larsen J K, Thomsen P H
Mood Disorders Research Unit, Aarhus University Psychiatric Hospital, Risskov, Denmark.
Acta Psychiatr Scand Suppl. 2003(419):1-22. doi: 10.1034/j.1600-0447.108.s419.1.x.
A subcommittee under the Danish Psychiatric Association and the Child and Adolescent Psychiatric Association in Denmark have recently developed national guidelines for the psychopharmacological treatment with lithium and antiepileptic drugs, and the present translation aims at contributing to the international discussion on the development of proper guidelines for the treatment of bipolar disorder. Among the antiepileptic drugs, the report deals with valproate, carbamazepine and lamotrigine and to a lesser extent with oxcarbazepine, gabapentin and topiramate. The various drugs will be reviewed, outlining the scientific evidence for mood-stabilizing properties and discussing major side effects, the most important interactions with other drugs and practical use. Special considerations during pregnancy and lactation, during treatment of children and adolescents and during treatment of the elderly will also be presented. Antidepressants and antipsychotics are beyond the scope of the report, but due to the mood-stabilizing properties of at least some of the atypical antipsychotics, these agents will be brought into some focus in connection with the overall treatment guidelines for the different phases of bipolar disorder given at the end of this report.
丹麦精神病学协会和丹麦儿童与青少年精神病学协会下属的一个小组委员会最近制定了关于锂盐和抗癫痫药物心理药理学治疗的国家指南，本译文旨在推动关于制定双相情感障碍恰当治疗指南的国际讨论。在抗癫痫药物中，该报告涉及丙戊酸盐、卡马西平和拉莫三嗪，对奥卡西平、加巴喷丁和托吡酯的讨论较少。将对各种药物进行综述，概述其情绪稳定特性的科学证据，并讨论主要副作用、与其他药物最重要的相互作用以及实际应用。还将介绍妊娠和哺乳期、儿童和青少年治疗期间以及老年人治疗期间的特殊注意事项。抗抑郁药和抗精神病药不在本报告范围内，但由于至少某些非典型抗精神病药具有情绪稳定特性，在本报告末尾给出的双相情感障碍不同阶段的总体治疗指南中，这些药物将受到一定关注。
