Tondo Leonardo, Alda Martin, Bauer Michael, Bergink Veerle, Grof Paul, Hajek Tomas, Lewitka Ute, Licht Rasmus W, Manchia Mirko, Müller-Oerlinghausen Bruno, Nielsen René E, Selo Marylou, Simhandl Christian, Baldessarini Ross J
International Consortium for Research on Mood & Psychotic Disorders, McLean Hospital, Belmont, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Int J Bipolar Disord. 2019 Jul 22;7(1):16. doi: 10.1186/s40345-019-0151-2.
Lithium has been used clinically for 70 years, mainly to treat bipolar disorder. Competing treatments and exaggerated impressions about complexity and risks of lithium treatment have led to its declining use in some countries, encouraging this update about its safe clinical use. We conducted a nonsystematic review of recent research reports and developed consensus among international experts on the use of lithium to treat major mood disorders, aiming for a simple but authoritative guide for patients and prescribers.
We summarized recommendations concerning safe clinical use of lithium salts to treat major mood disorders, including indications, dosing, clinical monitoring, adverse effects and use in specific circumstances including during pregnancy and for the elderly.
Lithium continues as the standard and most extensively evaluated treatment for bipolar disorder, especially for long-term prophylaxis.
锂已在临床应用70年，主要用于治疗双相情感障碍。其他竞争性治疗方法以及对锂治疗复杂性和风险的夸大印象导致其在一些国家的使用减少，促使对其安全临床应用进行此次更新。我们对近期研究报告进行了非系统性综述，并就锂治疗主要心境障碍的应用在国际专家间达成共识，旨在为患者和开处方者提供一份简洁而权威的指南。
我们总结了关于锂盐安全临床应用以治疗主要心境障碍的建议，包括适应证、剂量、临床监测、不良反应以及在特定情况下的应用，包括孕期和老年患者。
锂仍然是双相情感障碍的标准治疗方法且是评估最为广泛的治疗方法，尤其是用于长期预防。
