Slatkin Neal E, Rhiner Michelle
Department of Supportive Care, Pain and Palliative Medicine, City of Hope National Medical Center, Duarte, California 91010, USA.
Pain Med. 2003 Sep;4(3):298-303. doi: 10.1046/j.1526-4637.2003.03032.x.
Ketamine oral rinse provided effective palliation of intractable mucositis pain in a 32-year-old woman with squamous carcinoma of the tongue undergoing radiation therapy. Pain at rest and with eating decreased with ketamine, allowing for a tapering of her opiate dose. No side effects of ketamine were reported. Treatment benefits most likely arose from the inhibition by ketamine of peripheral N-methyl D-aspartate receptors, though other mechanisms of action may have been contributory. Further evaluation of topical ketamine in the treatment of mucositis-related pain, and, potentially, other causes of inflammatory oral pain, are warranted.
氯胺酮口腔含漱液有效缓解了一名32岁接受放射治疗的舌鳞状细胞癌女性患者的顽固性粘膜炎疼痛。使用氯胺酮后，静息和进食时的疼痛均减轻，使其阿片类药物剂量得以逐渐减少。未报告氯胺酮的副作用。治疗效果最可能源于氯胺酮对周围N-甲基-D-天冬氨酸受体的抑制作用，不过其他作用机制可能也有一定作用。有必要进一步评估局部使用氯胺酮治疗粘膜炎相关疼痛以及可能的其他炎性口腔疼痛病因的效果。
