Feld J J, Heathcote E J
Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
J Gastroenterol Hepatol. 2003 Oct;18(10):1118-28. doi: 10.1046/j.1440-1746.2003.03165.x.
Primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) are chronic liver diseases that likely have an autoimmune basis to their pathogenesis. Although significant strides have been made in the clinical management of these conditions, their pathogenesis remains obscure. Understanding of various epidemiological factors may shed light on predisposing or causative factors for these diseases. Most is known about the epidemiology of PBC, with only minimal information on that of PSC and AIH. In this review, the current data on the epidemiology of PBC, AIH and PSC are summarized and suggestions are made for future work in this important area.
原发性胆汁性肝硬化（PBC）、自身免疫性肝炎（AIH）和原发性硬化性胆管炎（PSC）是慢性肝病，其发病机制可能具有自身免疫基础。尽管在这些疾病的临床管理方面已取得显著进展，但其发病机制仍不清楚。了解各种流行病学因素可能有助于揭示这些疾病的易感因素或病因。关于PBC的流行病学了解最多，而关于PSC和AIH的信息则很少。在本综述中，总结了目前关于PBC、AIH和PSC流行病学的资料，并对这一重要领域的未来工作提出了建议。
