Department of Geriatrics, Chun'an First People's Hospital (Chun'an Branch of Zhejiang Provincial People's Hospital), Hangzhou, 311700, Zhejiang Province, China.
Department of Endocrinology, Chun'an First People's Hospital (Chun'an Branch of Zhejiang Provincial People's Hospital), Hangzhou, 311700, Zhejiang Province, China.
Arch Dermatol Res. 2024 Aug 20;316(8):549. doi: 10.1007/s00403-024-03331-3.
Rosacea and autoimmune liver diseases (AILDs) are diseases closely associated with immune system abnormalities. AILDs primarily includes autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). Currently, research on the association between these two conditions is limited. Therefore, this study employed the bidirectional Mendelian randomization (MR) method to investigate potential causal relationships between rosacea and AILDs based on genetic predictions. Summary data related to Rosacea, AIH, PSC, and PBC were obtained from public genome-wide association studies (GWAS). The inverse variance weighted (IVW) method was used as the primary analytical approach, supplemented by the MR-Egger, weighted mode method, weighted median, and simple mode. A series of sensitivity analyses were also conducted to identify heterogeneity and pleiotropy effects. The MR analysis results indicated a significant increase in the risk of rosacea being associated with PBC (OR = 1.09, 95% CI = 1.02-1.18, P = 0.014), but no such association was found with AIH or PSC. Furthermore, this study did not find a significant impact of rosacea on the risk of AILDs. This study represents the first in-depth exploration of the potential causal relationship between rosacea and AILDs using MR analysis. Thes findings suggest an increased risk of rosacea among PBC patients.
酒渣鼻与自身免疫性肝病（AILDs）是与免疫系统异常密切相关的疾病。AILDs 主要包括自身免疫性肝炎（AIH）、原发性胆汁性胆管炎（PBC）和原发性硬化性胆管炎（PSC）。目前，关于这两种疾病之间关联的研究有限。因此，本研究采用双向孟德尔随机化（MR）方法，基于遗传预测，探讨酒渣鼻与 AILDs 之间潜在的因果关系。酒渣鼻、AIH、PSC 和 PBC 的汇总数据来自公共全基因组关联研究（GWAS）。采用逆方差加权（IVW）法作为主要分析方法，辅之以 MR-Egger、加权中位数和简单模式。还进行了一系列敏感性分析，以识别异质性和多效性效应。MR 分析结果表明，酒渣鼻与 PBC 风险增加显著相关（OR=1.09，95%CI=1.02-1.18，P=0.014），但与 AIH 或 PSC 无显著相关性。此外，本研究未发现酒渣鼻对 AILDs 风险有显著影响。本研究首次使用 MR 分析深入探讨了酒渣鼻与 AILDs 之间潜在的因果关系。这些发现表明 PBC 患者中酒渣鼻的风险增加。
