15-脱氧-Δ12,14-前列腺素J2：内源性过氧化物酶体增殖物激活受体γ配体还是次要的类花生酸降解产物？
15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?
作者信息
Powell William S
机构信息
Meakins-Christie Laboratories and Department of Medicine, McGill University, 3626 St. Urbain Street, Montreal, Quebec H2X 2P2, Canada.
出版信息
J Clin Invest. 2003 Sep;112(6):828-30. doi: 10.1172/JCI19796.
Abstract
15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) affects gene transcription by activating PPARgamma and by covalent addition to transcription factors and signaling molecules, However, it is not known whether the high concentrations of 15d-PGJ2 required for these responses are consistent with physiological levels. A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.
摘要
15-脱氧-Δ12,14-前列腺素J2（15d-PGJ2）通过激活过氧化物酶体增殖物激活受体γ（PPARγ）以及与转录因子和信号分子进行共价加成来影响基因转录。然而，这些反应所需的高浓度15d-PGJ2是否与生理水平一致尚不清楚。一项新的研究表明，体内15d-PGJ2的水平实际上比诱导该分子许多生物学效应所需的水平低几个数量级。
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