Wilcox-Adelman Sarah A, Denhez Fabienne, Iwabuchi Tokuro, Saoncella Stefania, Calautti Enzo, Goetinck Paul F
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Glycoconj J. 2002 May-Jun;19(4-5):305-13. doi: 10.1023/A:1025304602057.
Studies examining the role of the cell-surface heparan sulfate proteoglycan syndecan-4 have yielded a plethora of information regarding its role in both cell-matrix and growth-factor mediated signaling events. Many of the initial conclusions drawn from such research placed syndecan-4 in a keystone position within various signaling pathways though the generation of syndecan-4 null mice have surprised many in the field by indicating otherwise. These contradictory results place researchers in the frustrating and yet exhilarating position of still asking the question, "What role does syndecan-4 play in life?"
对细胞表面硫酸乙酰肝素蛋白聚糖syndecan-4的作用进行研究，已经产生了大量关于其在细胞-基质和生长因子介导的信号传导事件中作用的信息。尽管syndecan-4基因敲除小鼠的产生表明情况并非如此，但从这类研究中得出的许多初步结论都将syndecan-4置于各种信号通路的关键位置，这让该领域的许多人感到惊讶。这些相互矛盾的结果使研究人员处于既沮丧又兴奋的境地，他们仍然在问：“syndecan-4在生命中起什么作用？”
