Bellin Robert, Capila Ishan, Lincecum John, Park Pyong Woo, Reizes Ofer, Bernfield Merton R
Division of Newborn Medicine, Department of Pediatrics, Children's Hospital, Harvard Medical School, 300 Longwood Ave., Enders-950, Boston, MA 02115, USA.
Glycoconj J. 2002 May-Jun;19(4-5):295-304. doi: 10.1023/A:1025352501148.
Heparan sulfate proteoglycans are known to modulate the activity of a large number of extracellular ligands thereby having the potential to regulate a great diversity of biological processes. The long-term studies in our laboratory have focused on the syndecans, one of the major cell surface heparan sulfate proteoglycan families. Most early work on syndecans involved biochemical studies that provided initial information on their structure and putative biological roles. In recent years, the development of transgenic organisms has allowed a more complete understanding of syndecan function. Studies with transgenic syndecan-1 and syndecan-3 mice have demonstrated an unforeseen role for syndecans in the regulation of feeding behavior. Syndecan-1 knockout mice display a reduced susceptibility to both Wnt-induced tumorigenesis and microbial pathogenesis. Experiments with Drosophila show that syndecan is first expressed upon cellularization in the early embryo, and may play a role in the early developmental stages of the fly. This review focuses on these diverse functions of the syndecans that have been elucidated by the use of transgenic mice and Drosophila as model systems.
硫酸乙酰肝素蛋白聚糖已知可调节大量细胞外配体的活性，因此有可能调节多种多样的生物过程。我们实验室的长期研究集中在syndecans上，它是主要的细胞表面硫酸乙酰肝素蛋白聚糖家族之一。早期关于syndecans的大多数工作都涉及生化研究，这些研究提供了关于其结构和假定生物学作用的初步信息。近年来，转基因生物的发展使人们能够更全面地了解syndecan的功能。对转基因syndecan-1和syndecan-3小鼠的研究表明，syndecans在调节摄食行为方面具有意想不到的作用。Syndecan-1基因敲除小鼠对Wnt诱导的肿瘤发生和微生物致病的易感性降低。对果蝇的实验表明，syndecan在早期胚胎细胞化时首次表达，并可能在果蝇的早期发育阶段发挥作用。本综述重点介绍了通过使用转基因小鼠和果蝇作为模型系统所阐明的syndecans的这些多样功能。
