Vandel S, Nezelof S, Bonin B, Mesnage A D, Bertschy G, Jacquet M, Bizouard P
Laboratoire de Pharmacologie Clinique, C.H.U., Besançon.
Encephale. 1992 Jul-Aug;18(4):401-5.
Benzodiazepine consumption has been studied in an inpatient population of a hospitalo-universitary center. The different user wards were classified by their cost or the importance of their benzodiazepine use. In a second step, the authors studied the prescription in the 6 most consumer medical wards. The most prescribed benzodiazepines were lorazepam and dipotassium clorazepate (27 and 23% respectively). In these six wards, on the day of the study, 48% of the 227 inpatients were taking benzodiazepines. Fourteen out of them were taking more than one of these drugs. In 80% of the cases, the patient was asking for the prescription. Out of the 110 inpatients found to have taken a benzodiazepine on the day of the study, 74 had already regularly used it during the years before hospital admission, mainly women (64%) and old people. Finally, out of the 227 inpatients studied, the hospitalization is a possible inducer of the benzodiazepine intake and dependence in 16% of the patients. The results are discussed against the background of other studies concerning benzodiazepine consumption.
在一家大学附属医院的住院患者群体中对苯二氮䓬类药物的使用情况进行了研究。根据其成本或苯二氮䓬类药物使用的重要性对不同的使用科室进行了分类。第二步,作者研究了6个使用量最大的内科病房的处方情况。处方量最大的苯二氮䓬类药物是劳拉西泮和氯氮䓬二钾(分别占27%和23%)。在这6个病房中,在研究当天,227名住院患者中有48%正在服用苯二氮䓬类药物。其中14人服用了不止一种此类药物。在80%的病例中,患者主动要求开具处方。在研究当天发现服用了苯二氮䓬类药物的110名住院患者中,74人在入院前几年就已经经常使用,主要是女性(64%)和老年人。最后,在研究的227名住院患者中,住院可能是16%的患者服用苯二氮䓬类药物并产生依赖的诱因。针对其他有关苯二氮䓬类药物使用情况的研究对结果进行了讨论。