Angrisani M, Cazzola M, Loffreda A, Losasso C, Lucarelli C, Rossi F
Institute of Pharmacology and Toxicology, 1st Medical School, Federico II University, Naples, Italy.
Int J Clin Pharmacol Res. 1992;12(4):165-71.
The influence of teicoplanin and aminophylline (theophylline ethylenediamine) on their mutual steady-state pharmacokinetics was studied in two parts, namely experimental and clinical studies. The concentrations of teicoplanin and aminophylline (theophylline) were evaluated at several times after intravenous administration of teicoplanin (3 and 15 mg/kg) and aminophylline (5 mg/kg) in 12 rabbits. Ten COPD patients were treated for 5 consecutive days with a short-term intravenous infusion of 240 mg aminophylline twice daily; ten more patients received for 5 days a short-term intravenous infusion of 200 mg teicoplanin twice daily. On the last day, blood samples were taken for teicoplanin and theophylline determination by means of the HPLC method. Subsequently, while aminophylline and teicoplanin were continued at the same dosage, the first ten patients received in addition a short-term intravenous infusion of 200 mg teicoplanin twice daily, and the second ten patients a short-term intravenous infusion of 240 mg aminophylline twice daily. After 5 days the serial assays of serum teicoplanin and theophylline were repeated. Our results demonstrated, in both experimental and clinical studies, no influence of theophylline on the steady-state pharmacokinetics of teicoplanin. Likewise teicoplanin had no significant effect on the steady-state pharmacokinetics of intravenous administration of theophylline in the form of aminophylline.
在两部分研究中考察了替考拉宁和氨茶碱（茶碱乙二胺）对彼此稳态药代动力学的影响，即实验研究和临床研究。在12只兔子静脉注射替考拉宁（3和15mg/kg）和氨茶碱（5mg/kg）后的多个时间点评估替考拉宁和氨茶碱（茶碱）的浓度。10例慢性阻塞性肺疾病（COPD）患者每天两次短期静脉输注240mg氨茶碱，连续治疗5天；另外10例患者每天两次短期静脉输注200mg替考拉宁，持续5天。在最后一天，采集血样，采用高效液相色谱法测定替考拉宁和茶碱。随后，在继续使用相同剂量氨茶碱和替考拉宁的同时，前10例患者额外每天两次短期静脉输注200mg替考拉宁，后10例患者每天两次短期静脉输注240mg氨茶碱。5天后重复血清替考拉宁和茶碱的系列测定。我们的结果表明，在实验研究和临床研究中，茶碱对替考拉宁的稳态药代动力学均无影响。同样，替考拉宁对以氨茶碱形式静脉给药的茶碱的稳态药代动力学也无显著影响。
