对健康成年人口服多种维生素片期间硫胺素和核黄素的血液水平及尿排泄情况
Blood levels and urinary excretion of thiamin and riboflavin during oral administration of multivitamin tablets to healthy adults.
作者信息
Itokawa Y, Kimura M, Nishino K, Mino M, Kitagawa M, Matsuoka M, Otsuka H
机构信息
Department of Hygiene, Faculty of Medicine, Kyoto University, Japan.
出版信息
J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:438-41. doi: 10.3177/jnsv.38.special_438.
PMID:1297784
Abstract
- The baseline blood thiamin concentration increased gradually during the long-term administration of TTFD, and the blood concentration was dose-dependent. The cumulative urinary thiamin excretion showed the same dose-dependence as the blood concentration. 2. The baseline blood riboflavin concentration also increased steadily during the administration period, but the increase was less than that of thiamin. Dose-dependence of the cumulative urinary excretion of riboflavin was noted. 3. No side effect were observed.
摘要
- 在长期给予三磷酸硫胺素（TTFD）期间，基线血硫胺素浓度逐渐升高，且血浓度呈剂量依赖性。硫胺素的累积尿排泄量与血浓度表现出相同的剂量依赖性。2. 在给药期间，基线血核黄素浓度也稳步升高，但升高幅度小于硫胺素。观察到核黄素累积尿排泄量的剂量依赖性。3. 未观察到副作用。
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