采用流动注射分析法测定药物制剂中的防腐剂氯甲酚。
The determination of the preservative, chlorocresol, in a pharmaceutical formulation by flow injection analysis.
作者信息
Bloomfield M S, Prebble K A
机构信息
Analytical Development Laboratory, Wellcome Foundation Limited, Dartford, Kent, UK.
出版信息
J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):775-8. doi: 10.1016/0731-7085(91)80079-o.
A flow injection analysis (FIA) procedure is described for the determination of chlorocresol in a parenteral pharmaceutical formulation. The product is directly injected into a carrier stream of water and subsequently reacted with a reagent stream of nitrous acid. The resulting brown nitro-derivative is determined spectrophotometrically at 400 nm. The method has been validated and should be applicable to chlorocresol in other pharmaceutical products and to compounds containing a phenolic ring, assuming absence of matrix interference.
描述了一种流动注射分析（FIA）方法，用于测定注射用药物制剂中的氯甲酚。将该产品直接注入水流载体中，随后与亚硝酸试剂流反应。所得棕色硝基衍生物在400nm处进行分光光度测定。该方法已经过验证，假设不存在基质干扰，应适用于其他药品中的氯甲酚以及含有酚环的化合物。
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