Gomo Z
Chemical Pathology Department, University of Zimbabwe Medical School, Avondale, Harare.
Cent Afr J Med. 1992 Sep;38(9):358-62.
The aim of this study was to determine serum fructosamine in a non-diabetic population and to evaluate the usefulness of fructosamine in the routine management of diabetic patients. The range of serum fructosamine in the non-diabetic population was 2.00-3.08 mmol/l (n = 300, mean 2.54 +/- 0.27). The mean level of fructosamine in the diabetic patients was 5.4 +/- 1.1 mmol/l at the beginning of the study and 3.5 +/- 0.4 mmol on the 12th week visit of the study. Significant differences in serum fructosamine levels were observed during the first visit and the 12th week visit p < 0.002. Serum fructosamine concentrations were significantly correlated with glycosylated haemoglobin at each subsequent visit (p < 0.001). No significant correlation between plasma glucose and fructosamine was found, suggesting the two parameters are markets for different time metabolic control. Routine use of serum fructosamine in management of diabetes is recommend.
本研究的目的是测定非糖尿病患者群体的血清果糖胺，并评估果糖胺在糖尿病患者常规管理中的作用。非糖尿病患者群体的血清果糖胺范围为2.00 - 3.08 mmol/l（n = 300，均值2.54 ± 0.27）。在研究开始时，糖尿病患者的果糖胺平均水平为5.4 ± 1.1 mmol/l，在研究的第12周复诊时为3.5 ± 0.4 mmol。在首次就诊和第12周复诊时观察到血清果糖胺水平存在显著差异（p < 0.002）。在每次后续就诊时，血清果糖胺浓度与糖化血红蛋白显著相关（p < 0.001）。未发现血糖与果糖胺之间存在显著相关性，这表明这两个参数是不同时间代谢控制的指标。建议在糖尿病管理中常规使用血清果糖胺。
